I get it:
% convert to PCM 16 bit
precision = 'int16';
fidr = fopen([a_filename(1:11), '_22050','.wav'], 'r'); % open .wav file to read
fidw = fopen([a_filename(1:11), '_22050','.pcm'], 'wb'); % open .pcm file to write
w = int16(fread(fidr, inf, precision));% read .wav file
fwrite(fidw, w, precision); % write .pcm file
fclose(fidr);
fclose(fidw);