SimBiology model for PK/PD of anticancer drugs

SimBiology model describing the effect of anticancer drugs on tumor growth kinetics

This is a SimBiology implementation of model characterizing the pharmacokinetic /pharmacodynamic (PK/PD) behavior of anticancer agents as described in the article, “Predictive Pharmacokinetic-Pharmacodynamic Modeling of Tumor Growth Kinetics in Xenograft Models after Administration of Anticancer Agents” by Simeoni et al. [1]
Reference:
[1] Simeoni M, Magni P, Cammia C, De Nicolao G, Croci V, Pesenti E, Germani M, Poggesi I, and Rocchetti M (2004) Predictive pharmacokinetic-pharmacodynamic modeling of tumor growth kinetics in xenograft models after administration of anticancer agents. Cancer Research 64: 1094-1101