Question about available PK models for practicing purposes

Hi all,

I have a question about SimBiology and PK models. Are there available any "simple", models for practicing, say a single- or 2-compartment model where one could plug-in PK parameter values and simulate a hypothetical drug? If not, is this something that the SimBiology community would like to distribute to other people who are beginners? This would be helpful to develop a feeling as to how a model behaves and reacts based on different PK parameter values and sometimes save time even. My colleagues and I would like to learn SimBiology for more advanced PK modeling but we thought that it would be more efficient if we could use a pre-developed one and adjust values etc. Videos and documentations are great but a hands-on example model would also be extremely helpful.

Thank you for your time!

Best regards,

Christos

Answer 1

[Fulden Buyukozturk]

Hi Christos,

A couple of thoughts:

• SimBiolog has a PK library. You can pick a 1 or 2 comp model from there, populate the parameter values/dosing and run. If you're running using Model Builder app, you can go Home->Model->Load model from PK library. If you're running from the command-line interface, please see this page.
• There are multiple example SimBiology models in the community site with associated publication references.

Hope these help you get started, please let me know.

Fulden

[Christos]

Hi Fulder,

Many thanks for your swift response! I will certainly check those suggestions and may get back to you with questions in case I have some.

Many thanks!

Christos