On further investigation, the issue is limited to bluetooth mice... I've used a USB mouse with no problem.
Matlab 2016a and higher: Mouse double click does not work
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ANDRE BUCCI on 24 Aug 2018
Edited: ANDRE BUCCI on 24 Aug 2018
I'm having the same issue... did anyone find any solution yet? I noticed that the problem (at least for me) is related to wireless mouse used in iMacs and MacMinis. It doesn't make sense though... MacBook with either trackpad or wireless mouse works normally. I used the same wireless mouse, with the same settings in a Mac mini and iMac and the problem occurred. Problem also persisted from matlab R2017a/b into R2018a. haven't tried in older versions. It's a pain to preview variables from workspace or access path bar.
Ed Marquez on 5 Apr 2017
I would recommend checking the charts in this link for MAC OS & MATLAB/Simulink. It is possible that this issue can be due to a non-supported setup (assuming MATLAB is related to the issue).
Check also if this is just specific to R2016a and your MAC OS. It would be helpful to see if using a previous or newer version of MATLAB changes this behavior. As @Rik also suggested, it could be a OS issue, but I don't know what version you are using with MATLAB.
Richard Allen on 11 Sep 2018
Same issue for me. It appears to be limited to Magic Mouse 2 and Matlab (not any other apps), but on a MacBook Pro.