Best way to perform 1000 regressions (regress function)

I need to do about 1000 regressions using regress(x,y). What is the best way to set my data up? all on one sheet somehow or in 1000 sheets, and what is the best way to automate the regressions? I need all the usual regression outputs such as r squares, coefficients, p values etc. I'm relatively new to matlab so detailed suggestions would be appreciated. thanks in advance!

[Star Strider]

What do your data look like (x and y)?

What is the problem you are solving?