How to filling the area bounded by the contour?

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How to filling the area bounded by the contour (brain tumor - red line)?
I use this code:
imshow (img);
hold on
edge = contour(GT, 'r' , 'Fill' , 'off' , 'linewidth' ,1);

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Image Analyst
Image Analyst il 4 Mar 2015
Modificato: Image Analyst il 4 Mar 2015
Lots of ways, like measuring all blobs and looking for which have a circularity near 1. Or extract the 2 biggest blobs, then take the smallest of those two (see attached demo). Plus other ways depending on what assumptions you make.
See my Image Segmentation Tutorial in my File Exchange to see how to do filtering based on size. You could extend it to filter based on size and circularity (= perimeter^2/(4*pi*Area)).

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