Build mechanistic systems biology models or PK/PD models
Build QSP, PBPK, PK/PD, and systems biology models graphically using a block diagram editor or programmatically using MATLAB® functions. Use doses to model various dosing regimens and use variants to represent biological variability and what-if scenarios.
|SimBiology Model Builder||Build QSP, PK/PD, and mechanistic systems biology models interactively|
|SimBiology Model Analyzer||Analyze QSP, PK/PD, and mechanistic systems biology models|
|Construct model object|
|Return SimBiology root object|
|Delete all model objects|
|Search for objects with specified constraints|
|Compare SimBiology models and diagram information|
|Get model components associated with SimBiology model comparison results|
|Visualize SimBiology model comparison results|
|Create compartment object|
|Add compartment to |
|Add observable object to SimBiology model|
|Create species object and add to compartment object within model object|
|Create parameter object and add to model or kinetic law object|
|Create reaction object and add to model object|
|Create rule object and add to model object|
|Add event object to model object|
|Construct SimBiology model from |
|Model and component information|
|Object containing expression for post-simulation calculations|
|Object containing compartment information|
|Object containing species information|
|Parameter and scope information|
|Object containing model reaction information|
|Kinetic law information for reaction|
|Hold rule for species and parameters|
|Store event information|
|Hold models, unit libraries, and abstract kinetic law libraries|
|Results of comparison between two SimBiology models and diagrams|
|Helper object to construct pharmacokinetic model|
|Used by |
|Define SimBiology model components’ roles|
- Create Model of Receptor-Ligand Kinetics
Create and simulate a simple receptor-ligand kinetics model using SimBiology apps.
- Incorporate SGLT2 Inhibition into Physiologically Based Glucose-Insulin Model Using SimBiology Model Builder
Update a glucose-insulin model to integrate sodium-glucose co-transporter 2 (SGLT2) receptor inhibition by a hypothetical compound.
- Construct a Simple Model
This example shows how to construct a simple model programmatically.
- Compare SimBiology Models
Compare any two SimBiology models to find out the differences between them.
- Model a Gene-Regulation Pathway
This example shows how to construct a simple gene-regulation model and simulate it.
- Create and Simulate a Model with a Custom Function
This example shows how to create a custom function and incorporate it in model simulation.
- Define Reaction Rates with Mass Action Kinetics
Use mass action kinetics to define zero-order, first-order, second-order, and reversible reactions.
- Define Reaction Rates with Enzyme Kinetics
Use differential equations, mass action kinetics, or Michaelis-Menten kinetics to define enzyme reactions.
- Events in SimBiology Models
In SimBiology, an event is a discrete transition in value of a quantity or expression in a model.
- Create Pharmacokinetic Models
SimBiology lets you create one-, two-, or multi-compartment pharmacokinetic models for model simulation and parameter estimation.
- What is a SimBiology Model?
A SimBiology model is a dynamic system described by a set of quantities and mathematical expressions.
- Species Object
species objectrepresents a species, which is the amount of a chemical or entity that participates in reactions.
- Doses in SimBiology Models
Use doses to model different dosing regimens.
- Variants in SimBiology Models
Use variants to store alternate parameter values and initial conditions of a model.
- Definitions and Evaluations of Rules in SimBiology Models
Rules are mathematical expressions that allow you to define or modify model quantities, namely compartment capacity, species amount, or parameter value.
- Definitions and Evaluations of Reactions in SimBiology Models
A reaction is a mathematical expression that describe a transformation, transport, or binding process that changes one or more species.
- SimBiology Model Matching Policy
SimBiology uses certain criteria and rules to compare models.